Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial
Background The aim of this study was to explore the effects of a low dose (LD) of 0.625 mg and a high dose (HD) of 2.5 mg of phenylcapsaicin (PC) on full squat (SQ) performance, active muscle (RPE-AM) and overall body (RPE-OB) ratings of perceived exertion, muscle damage, protein breakdown, metaboli...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of the International Society of Sports Nutrition |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15502783.2023.2204083 |
| _version_ | 1797678942377738240 |
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| author | Pablo Jiménez-Martínez Pedro Jesús Cornejo-Daza Juan Sánchez-Valdepeñas Iván Asín-Izquierdo Clara Cano-Castillo Carlos Alix-Fages Fernando Pareja-Blanco Juan C. Colado |
| author_facet | Pablo Jiménez-Martínez Pedro Jesús Cornejo-Daza Juan Sánchez-Valdepeñas Iván Asín-Izquierdo Clara Cano-Castillo Carlos Alix-Fages Fernando Pareja-Blanco Juan C. Colado |
| author_sort | Pablo Jiménez-Martínez |
| collection | DOAJ |
| description | Background The aim of this study was to explore the effects of a low dose (LD) of 0.625 mg and a high dose (HD) of 2.5 mg of phenylcapsaicin (PC) on full squat (SQ) performance, active muscle (RPE-AM) and overall body (RPE-OB) ratings of perceived exertion, muscle damage, protein breakdown, metabolic response, and 24-h recovery in comparison to placebo (PLA). Method Twenty-five resistance-trained males (age = 21.00 ± 2.15 years, SQ 1-repetition maximum [1RM] normalized = 1.66 ± 0.22 kg) were enrolled in this randomized, triple-blinded, placebo-controlled, crossover trial. Participants completed 2 weekly sessions per condition (LD, HD, and PLA). The first session consisted of pre-blood testing of lactate, urea, and aspartate aminotransferases (AST) and 2 SQ repetitions with 60% 1RM followed by the resistance exercise protocol, which consisted of SQ sets of 3 × 8 × 70% 1RM monitoring lifting velocity. RPE-OB and RPE-AM were assessed after each set. After the first session, 2 SQ repetitions with 60% 1RM were performed, and blood lactate and urea posttests were collected. After 24 h, AST posttest and 1 × 2 × 60% 1RM were determined as biochemical and mechanical fatigue outcomes. Results HD reported significant differences for RPE-AM, AST, and SQ performance compared to LD and PLA. Post-hoc analyses revealed that HD attained faster velocities in SQ than LD (p = 0.008). HD induced a lower RPE-AM when compared with LD (p = 0.02) and PLA (p = 0.004). PLA resulted in higher AST concentrations at 24-h post than HD (p = 0.02). No significant differences were observed for the rest of the comparisons. Conclusions This study suggests that PC may favorably influence SQ performance, RPE-AM, and muscle damage compared to PLA. However, HD exhibited most of the biochemical and mechanical anti-fatigue effects instead of LD. |
| first_indexed | 2024-03-11T23:07:13Z |
| format | Article |
| id | doaj.art-2acca3b2ad7f40278f105505997397ff |
| institution | Directory Open Access Journal |
| issn | 1550-2783 |
| language | English |
| last_indexed | 2024-03-11T23:07:13Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of the International Society of Sports Nutrition |
| spelling | doaj.art-2acca3b2ad7f40278f105505997397ff2023-09-21T12:43:11ZengTaylor & Francis GroupJournal of the International Society of Sports Nutrition1550-27832023-12-0120110.1080/15502783.2023.22040832204083Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trialPablo Jiménez-Martínez0Pedro Jesús Cornejo-Daza1Juan Sánchez-Valdepeñas2Iván Asín-Izquierdo3Clara Cano-Castillo4Carlos Alix-Fages5Fernando Pareja-Blanco6Juan C. Colado7University of ValenciaUniversidad Pablo de OlavideUniversidad Pablo de OlavideUniversidad Pablo de OlavideUniversidad Pablo de OlavideUniversity of ValenciaUniversidad Pablo de OlavideUniversity of ValenciaBackground The aim of this study was to explore the effects of a low dose (LD) of 0.625 mg and a high dose (HD) of 2.5 mg of phenylcapsaicin (PC) on full squat (SQ) performance, active muscle (RPE-AM) and overall body (RPE-OB) ratings of perceived exertion, muscle damage, protein breakdown, metabolic response, and 24-h recovery in comparison to placebo (PLA). Method Twenty-five resistance-trained males (age = 21.00 ± 2.15 years, SQ 1-repetition maximum [1RM] normalized = 1.66 ± 0.22 kg) were enrolled in this randomized, triple-blinded, placebo-controlled, crossover trial. Participants completed 2 weekly sessions per condition (LD, HD, and PLA). The first session consisted of pre-blood testing of lactate, urea, and aspartate aminotransferases (AST) and 2 SQ repetitions with 60% 1RM followed by the resistance exercise protocol, which consisted of SQ sets of 3 × 8 × 70% 1RM monitoring lifting velocity. RPE-OB and RPE-AM were assessed after each set. After the first session, 2 SQ repetitions with 60% 1RM were performed, and blood lactate and urea posttests were collected. After 24 h, AST posttest and 1 × 2 × 60% 1RM were determined as biochemical and mechanical fatigue outcomes. Results HD reported significant differences for RPE-AM, AST, and SQ performance compared to LD and PLA. Post-hoc analyses revealed that HD attained faster velocities in SQ than LD (p = 0.008). HD induced a lower RPE-AM when compared with LD (p = 0.02) and PLA (p = 0.004). PLA resulted in higher AST concentrations at 24-h post than HD (p = 0.02). No significant differences were observed for the rest of the comparisons. Conclusions This study suggests that PC may favorably influence SQ performance, RPE-AM, and muscle damage compared to PLA. However, HD exhibited most of the biochemical and mechanical anti-fatigue effects instead of LD.http://dx.doi.org/10.1080/15502783.2023.2204083trpv1ergogenic aidcapsaicinoidsvelocity-based trainingvelocity loss |
| spellingShingle | Pablo Jiménez-Martínez Pedro Jesús Cornejo-Daza Juan Sánchez-Valdepeñas Iván Asín-Izquierdo Clara Cano-Castillo Carlos Alix-Fages Fernando Pareja-Blanco Juan C. Colado Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial Journal of the International Society of Sports Nutrition trpv1 ergogenic aid capsaicinoids velocity-based training velocity loss |
| title | Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial |
| title_full | Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial |
| title_fullStr | Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial |
| title_full_unstemmed | Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial |
| title_short | Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial |
| title_sort | effects of different phenylcapsaicin doses on resistance training performance muscle damage protein breakdown metabolic response ratings of perceived exertion and recovery a randomized triple blinded placebo controlled crossover trial |
| topic | trpv1 ergogenic aid capsaicinoids velocity-based training velocity loss |
| url | http://dx.doi.org/10.1080/15502783.2023.2204083 |
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