7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase

7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase

Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation improves cognition is unclear as well. Pyridoxal 5’-phosphate p...

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Bibliographic Details
Main Authors: Marian Brenner, Christoph Zink, Linda Witzinger, Angelika Keller, Kerstin Hadamek, Sebastian Bothe, Martin Neuenschwander, Carmen Villmann, Jens Peter von Kries, Hermann Schindelin, Elisabeth Jeanclos, Antje Gohla
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-06-01
Series:eLife
Subjects:
vitamin B6
cognition
pyridoxal phosphatase
pyridoxal phosphatase inhibitor
7,8-dihydroxyflavone
X-ray crystal structure
Online Access:https://elifesciences.org/articles/93094

Internet

https://elifesciences.org/articles/93094

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