Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration

Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration

Abstract To control sprouting angiogenesis, endothelial Notch signaling suppresses tip cell formation, migration, and proliferation while promoting barrier formation. Each of these responses may be regulated by distinct Notch-regulated effectors. Notch activity is highly dynamic in sprouting endothe...

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Bibliographic Details
Main Authors: Bhairavi Swaminathan, Seock-Won Youn, L. A. Naiche, Jing Du, Stephanie R. Villa, Jordan B. Metz, Huijuan Feng, Chaolin Zhang, Raphael Kopan, Peter A. Sims, Jan K. Kitajewski
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05666-1

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https://doi.org/10.1038/s41598-022-05666-1

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