SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells

SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells

The pregnane X receptor (PXR) has been well-established as a critical mediator in regulating important drug metabolizing enzymes and transporter proteins, including cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp). Previous studies identified that PXR served as a molecular target of SUMOylatio...

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Bibliographic Details
Main Authors: Huasen Tan, Chenshu Xu, Hang Zeng, Ying Wang, Yingmei Li, Xiaomei Fan, Pan Chen, Yiming Jiang, Xiao Chen, Min Huang, Huichang Bi
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Journal of Pharmacological Sciences
Subjects:
Pregnane X receptor
SUMOylation
Transcriptional activity
CYP3A4
P-gp
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002285

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http://www.sciencedirect.com/science/article/pii/S1347861315002285

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