Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy.

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy.

BACKGROUND: Variations within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) are associated with the risk to develop inflammatory bowel disease (IBD). PTPN22 is involved in the regulation of T- and B-cell receptor signaling, but although it is highly expressed in...

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Bibliographic Details
Main Authors: Marianne R Spalinger, Silvia Lang, Stephan R Vavricka, Michael Fried, Gerhard Rogler, Michael Scharl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3753240?pdf=render

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http://europepmc.org/articles/PMC3753240?pdf=render

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