Synthesis of New <i>bis</i>-furanyl-pyrrolo[3,4-<i>b</i>]pyridin-5-ones via the Ugi-Zhu Reaction and Docking Studies on the Main Protease (M<sup>Pro</sup>) from SARS-CoV-2
The synthesis of five new <i>bis</i>-furanyl-pyrrolo[3,4-<i>b</i>]pyridin-5-ones in 30 to 40% yields through a domino sequence based on the Ugi-Zhu three-component reaction is described. Then, on the main protease M<sup>Pro</sup> (PDB: 6lu7) from the SARS-CoV-2, t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
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| Series: | Chemistry Proceedings |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4583/8/1/84 |