Synthesis of New <i>bis</i>-furanyl-pyrrolo[3,4-<i>b</i>]pyridin-5-ones via the Ugi-Zhu Reaction and Docking Studies on the Main Protease (M<sup>Pro</sup>) from SARS-CoV-2

Synthesis of New <i>bis</i>-furanyl-pyrrolo[3,4-<i>b</i>]pyridin-5-ones via the Ugi-Zhu Reaction and Docking Studies on the Main Protease (M<sup>Pro</sup>) from SARS-CoV-2

The synthesis of five new <i>bis</i>-furanyl-pyrrolo[3,4-<i>b</i>]pyridin-5-ones in 30 to 40% yields through a domino sequence based on the Ugi-Zhu three-component reaction is described. Then, on the main protease M<sup>Pro</sup> (PDB: 6lu7) from the SARS-CoV-2, t...

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Bibliographic Details
Main Authors: Ivette Morales-Salazar, Sandra L. Castañón-Alonso, Daniel Canseco-González, Erik Díaz-Cervantes, Eduardo González-Zamora, Alejandro Islas-Jácome
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Chemistry Proceedings
Subjects:
Ugi-Zhu reaction
polyheterocycles
docking
COVID-19
SARS-CoV-2
main protease M<sup>Pro</sup>
Online Access:https://www.mdpi.com/2673-4583/8/1/84

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