The neuroprotective N-terminal amyloid-β core hexapeptide reverses reactive gliosis and gliotoxicity in Alzheimer’s disease pathology models

The neuroprotective N-terminal amyloid-β core hexapeptide reverses reactive gliosis and gliotoxicity in Alzheimer’s disease pathology models

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by accumulation of extracellular amyloid beta (Aβ) and intracellular neurofibrillary tangles, leading to chronic activation of astrocytes and microglia and persistent neuroinflammation. Aβ-linked a...

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Bibliographic Details
Main Authors: Megan J. Lantz, Alyssa M. Roberts, Donovan D. Delgado, Robert A. Nichols
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Alzheimer’s disease
Amyloid-β
Protective peptides
Gliosis
Online Access:https://doi.org/10.1186/s12974-023-02807-9

Internet

https://doi.org/10.1186/s12974-023-02807-9

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