Dysregulated hepatic UDP-glucuronosyltransferases and flavonoids glucuronidation in experimental colitis

Dysregulated hepatic UDP-glucuronosyltransferases and flavonoids glucuronidation in experimental colitis

Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the most important phase II mechanisms, facilitating drug clearance via conjugation of glucuronic acid with polar groups of xenobiotics. Accumulating evidence suggests that IBDs impact drug disposition, but whether and how IB...

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Bibliographic Details
Main Authors: Wanying Zeng, Xiaojing Liu, Yangyang Wu, Yuting Cai, Zhennan Li, Fei Ye, Yuanhong Sun, Feng Li, Huijie Xing, Shuai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
UGTs (UDP-glycosyltransferases)
glucuronidation
colitis
DSS
baicalein
puerarin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1053610/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1053610/full

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