Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukaemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model

Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukaemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model

Acute myeloid leukaemia (AML) is one of the most common types of haematopoietic malignancy. Ribonucleotide reductase (RNR) is a key enzyme required for DNA synthesis and cell proliferation, and its small subunit RRM2 plays a key role for the enzymatic activity. We predicted monobenzone (MB) as a pot...

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Bibliographic Details
Main Authors: Jingwen Dong, Tingting Zhong, Zhijian Xu, Haiyi Chen, Xianjun Wang, Lili Yang, Zhiyuan Lou, Yuanling Xu, Tingjun Hou, Rongzhen Xu, Weiliang Zhu, Jimin Shao
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
acute myeloid leukaemia
ribonucleotide reductase
monobenzone
anti-proliferative activity
combination therapy
Online Access:https://www.mdpi.com/2072-6694/14/19/4710

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https://www.mdpi.com/2072-6694/14/19/4710

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