Factor VIII moiety of recombinant Factor VIII Fc fusion protein impacts Fc effector function and CD16+ NK cell activation

Factor VIII moiety of recombinant Factor VIII Fc fusion protein impacts Fc effector function and CD16+ NK cell activation

Recombinant Factor VIII-Fc fusion protein (rFVIIIFc) is an enhanced half-life therapeutic protein product used for the management of hemophilia A. Recent studies have demonstrated that rFVIIIFc interacts with Fc gamma receptors (FcγR) resulting in the activation or inhibition of various FcγR-express...

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Bibliographic Details
Main Authors: H.A. Daniel Lagassé, Jiayi Ou, Zuben E. Sauna, Basil Golding
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
Fc-fusion
Fc gamma receptors
natural killer cells
Fc gamma receptor IIIa
Factor VIII light chain
discoidin domain
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1341013/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1341013/full

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