Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors.

Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors.

Members of the EGF-CFC family play essential roles in embryonic development and have been implicated in tumorigenesis. The TGFbeta signals Nodal and Vg1/GDF1, but not Activin, require EGF-CFC coreceptors to activate Activin receptors. We report that the TGFbeta signaling antagonist Lefty also acts t...

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Bibliographic Details
Main Authors: Simon K Cheng, Felix Olale, Ali H Brivanlou, Alexander F Schier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2004-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC340941?pdf=render

Internet

http://europepmc.org/articles/PMC340941?pdf=render

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