Top-down mechanisms of anesthetic-induced unconsciousness

The question of how structurally and pharmacologically diverse general anesthetics disrupt consciousness has persisted since the 19th century. There has traditionally been a significant focus on bottom-up mechanisms of anesthetic action, in terms of sensory processing, arousal systems and structura...

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Bibliographic Details
Main Author: George A. Mashour
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Systems Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00115/full