Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis

Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis

Abstract The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue, we examined the cellular origin and progression of...

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Bibliographic Details
Main Authors: Yuriy Pomeshchik, Erika Velasquez, Jeovanis Gil, Oxana Klementieva, Ritha Gidlöf, Marie Sydoff, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gunilla Westergren-Thorsson, Gunnar K. Gouras, Melinda Rezeli, Laurent Roybon
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Acta Neuropathologica Communications
Subjects:
Induced pluripotent stem cells
Alzheimer’s disease
Hippocampal spheroids
Intracerebral transplantation
Proteomic analysis
Human post-mortem tissue
Online Access:https://doi.org/10.1186/s40478-023-01649-z

Internet

https://doi.org/10.1186/s40478-023-01649-z

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