Tumor-Specific Monomethyl Auristatin E (MMAE) Prodrug Nanoparticles for Safe and Effective Chemotherapy

Tumor-Specific Monomethyl Auristatin E (MMAE) Prodrug Nanoparticles for Safe and Effective Chemotherapy

A prodrug is bioreversible medication that is specifically converted to the active drugs by enzymes overexpressed in the tumor microenvironment, which can considerably reduce the chemotherapy-induced side effects. However, prodrug strategies usually have low antitumor efficacy compared to free drugs...

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Bibliographic Details
Main Authors: Hanhee Cho, Man Kyu Shim, Yujeong Moon, Sukyung Song, Jinseong Kim, Jiwoong Choi, Jeongrae Kim, Youngjoo Lee, Jung Yeon Park, Yongju Kim, Cheol-Hee Ahn, Mi Ra Kim, Hong Yeol Yoon, Kwangmeyung Kim
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
prodrug
monomethyl auristatin E
nanoparticle
targeted therapy
chemotherapy
Online Access:https://www.mdpi.com/1999-4923/14/10/2131

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https://www.mdpi.com/1999-4923/14/10/2131

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