Immune cell composition and functional marker dynamics from multiplexed immunohistochemistry to predict response to neoadjuvant chemotherapy in the WSG-ADAPT-TN trial

Immune cell composition and functional marker dynamics from multiplexed immunohistochemistry to predict response to neoadjuvant chemotherapy in the WSG-ADAPT-TN trial

Background The association of early changes in the immune infiltrate during neoadjuvant chemotherapy (NACT) with pathological complete response (pCR) in triple-negative breast cancer (TNBC) remains unexplored.Methods Multiplexed immunohistochemistry was performed in matched tumor biopsies obtained a...

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Bibliographic Details
Main Authors: Eva-Maria Grischke, Nadia Harbeck, Michael Braun, Katarzyna Jozwiak, Michael Hauptmann, Claudia Schumacher, Monika Graeser, Friedrich Feuerhake, Oleg Gluz, Valery Volk, Matthias Christgen, Sherko Kuemmel, Helmut Forstbauer, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Cornelia Kolberg-Liedtke, Ronald Kates, Rachel Wuerstlein, Ulrike Nitz, Hans Heinrich Kreipe
Format: Article
Language:English
Published: BMJ Publishing Group 2021-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/5/e002198.full

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https://jitc.bmj.com/content/9/5/e002198.full

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