Effects of Aβ-derived peptide fragments on fibrillogenesis of Aβ

Abstract Amyloid β (Aβ) peptide aggregation plays a central role in Alzheimer’s disease (AD) etiology. AD drug candidates have included small molecules or peptides directed towards inhibition of Aβ fibrillogenesis. Although some Aβ-derived peptide fragments suppress Aβ fibril growth, comprehensive a...

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Bibliographic Details
Main Authors: Faisal Abedin, Nabin Kandel, Suren A. Tatulian
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-98644-y