GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

Ribosome-associated quality control pathways respond to defects in translational elongation to recycle arrested ribosomes and degrade aberrant polypeptides and mRNAs. Loss of a tRNA gene leads to ribosomal pausing that is resolved by the translational GTPase GTPBP2, and in its absence causes neuron...

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Bibliographic Details
Main Authors: Markus Terrey, Scott I Adamson, Alana L Gibson, Tianda Deng, Ryuta Ishimura, Jeffrey H Chuang, Susan L Ackerman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
tRNA-Arg-TCT-4-1
ribosome stalling
cerebellum
granule cells
hippocampus
retina
Online Access:https://elifesciences.org/articles/62731

Internet

https://elifesciences.org/articles/62731

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