Filamin A pre-mRNA editing modulates vascularization and tumor growth

Filamin A pre-mRNA editing modulates vascularization and tumor growth

Adenosine to inosine (A to I) editing is mediated by adenosine deaminases acting on RNA (ADAR) enzymes. Inosines are interpreted as guanosines by the translational machinery. Consequently, A to I editing in mRNAs can lead to their recoding and the formation of proteins not encoded in the genome. Fil...

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Bibliographic Details
Main Authors: Mamta Jain, Greeshma Manjaly, Kathrin Maly, Margreet R. de Vries, Michael Janisiw, Lisa König, Anne Yaël Nossent, Michael F. Jantsch
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA editing
filamin A
RNA editing
cell migration
angiogenesis hindlimb ischemia
endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122002967

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http://www.sciencedirect.com/science/article/pii/S2162253122002967

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