Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis

Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis

The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight and obese populations, resulting in overdosing and ineffective resource util...

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Bibliographic Details
Main Authors: Alanna McEneny-King, Pierre Chelle, Severine Henrard, Cedric Hermans, Alfonso Iorio, Andrea N. Edginton
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Pharmaceutics
Subjects:
hemophilia A
conventional factor VIII
dose metrics
obesity
population pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/9/4/47

Internet

https://www.mdpi.com/1999-4923/9/4/47

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