Metabolic effects of bezafibrate in mitochondrial disease

Metabolic effects of bezafibrate in mitochondrial disease

Abstract Mitochondrial disorders affect 1/5,000 and have no cure. Inducing mitochondrial biogenesis with bezafibrate improves mitochondrial function in animal models, but there are no comparable human studies. We performed an open‐label observational experimental medicine study of six patients with...

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Bibliographic Details
Main Authors: Hannah Steele, Aurora Gomez‐Duran, Angela Pyle, Sila Hopton, Jane Newman, Renae J Stefanetti, Sarah J Charman, Jehill D Parikh, Langping He, Carlo Viscomi, Djordje G Jakovljevic, Kieren G Hollingsworth, Alan J Robinson, Robert W Taylor, Leonardo Bottolo, Rita Horvath, Patrick F Chinnery
Format: Article
Language:English
Published: Springer Nature 2020-03-01
Series:EMBO Molecular Medicine
Subjects:
bezafibrate
metabolomics
mitochondrial disorder
mitochondrial DNA
mitochondrial encephalomyopathy
Online Access:https://doi.org/10.15252/emmm.201911589

Internet

https://doi.org/10.15252/emmm.201911589

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