Targeting Proteasomes and the MHC Class I Antigen Presentation Machinery to Treat Cancer, Infections and Age-Related Diseases

Targeting Proteasomes and the MHC Class I Antigen Presentation Machinery to Treat Cancer, Infections and Age-Related Diseases

The majority of T-cell responses involve proteasome-dependent protein degradation and the downstream presentation of oligopeptide products complexed with major histocompatibility complex (MHC) class I (MHC-I) molecules to peptide-restricted CD8<sup>+</sup> T-cells. However, evasion of ho...

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Bibliographic Details
Main Authors: Priyanka S. Rana, James J. Ignatz-Hoover, James J. Driscoll
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cancers
Subjects:
antigen presentation
immune checkpoint inhibitors
immunopeptidome
immunoproteasome
proteasome inhibitors
ubiquitin–proteasome system
Online Access:https://www.mdpi.com/2072-6694/15/23/5632

Internet

https://www.mdpi.com/2072-6694/15/23/5632

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