Gene Expression Analysis of Adapted Insect Cells during Influenza VLP Production Using RNA-Sequencing

Gene Expression Analysis of Adapted Insect Cells during Influenza VLP Production Using RNA-Sequencing

Adaptive laboratory evolution has been used to improve production of influenza hemagglutinin (HA)-displaying virus-like particles (VLPs) in insect cells. However, little is known about the underlying biological mechanisms promoting higher HA-VLP expression in such adapted cell lines. In this article...

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Bibliographic Details
Main Authors: Marco Silvano, Ricardo Correia, Nikolaus Virgolini, Colin Clarke, Paula M. Alves, Inês A. Isidro, António Roldão
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
insect cells
baculovirus expression system
influenza VLP
RNA sequencing
pathway analysis
Online Access:https://www.mdpi.com/1999-4915/14/10/2238

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https://www.mdpi.com/1999-4915/14/10/2238

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