Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF

Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF

CIGB-247 is a vascular endothelial growth factor (VEGF)-based active immunotherapy and it is currently under investigation for cancer treatment. This specific active immunotherapy encompasses two vaccine candidates that use a human VEGF variant molecule as antigen, in combination with two clinically...

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Bibliographic Details
Main Authors: Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Marta Ayala Ávila
Format: Article
Language:English
Published: Taylor & Francis Group 2022-10-01
Series:Platelets
Subjects:
active immunotherapy
cigb-247
endocytosis
platelet
vegf
α-granules
Online Access:http://dx.doi.org/10.1080/09537104.2022.2042235

Internet

http://dx.doi.org/10.1080/09537104.2022.2042235

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