Evaluation of Mycobacterium avium subsp. paratuberculosis isocitrate lyase (IcL) and ABC transporter (BacA) knockout mutants as vaccine candidates

Evaluation of Mycobacterium avium subsp. paratuberculosis isocitrate lyase (IcL) and ABC transporter (BacA) knockout mutants as vaccine candidates

There has been little success in controlling Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis, due to suboptimal diagnostics and the ineffectiveness of available vaccines. By knocking out BacA and IcL, genes required for MAP survival in dairy calves, two live-attenuated vaccine...

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Bibliographic Details
Main Authors: Razieh Eshraghisamani, Rakel Arrazuria, Lucy Luo, Jeroen De Buck
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium avium subsp. paratuberculosis
live-attenuated vaccines
dairy calves
immune responses
control programs
vaccine development
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1149419/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1149419/full

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