Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase

Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase

Abstract Our lab has previously demonstrated Riluzole to be an effective drug in inhibiting proliferation and inducing apoptosis in both human and mouse osteosarcoma. Yes-associated protein is a transcription co-activator, known to be involved in cell proliferation or apoptosis depending on its prot...

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Bibliographic Details
Main Authors: Marian Raghubir, Syeda M. Azeem, Rifat Hasnat, Chowdhury N. Rahman, Linda Wong, Salina Yan, Yu Qi Huang, Raquel Zhagui, Angelina Blyufer, Iffat Tariq, Cassey Tam, Sonam Lhamo, Lucas Cecilio, Yesmin Chowdhury, Shraddha ChandThakuri, Shahana S. Mahajan
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00439-8

Internet

https://doi.org/10.1038/s41598-021-00439-8

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