Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects

Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects

ABSTRACT Type I interferons (IFNs) are key players in the antiviral immune response. Interferon alpha (IFN-α) belongs to this class of IFNs and comprises 12 subtypes that differ from each other in their binding affinities for a common receptor and, thus, in their signaling potencies. Recent data sug...

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Bibliographic Details
Main Authors: Erika Schlaepfer, Audrey Fahrny, Maarja Gruenbach, Stefan P. Kuster, Viviana Simon, Gideon Schreiber, Roberto F. Speck
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mSphere
Subjects:
antiviral therapy
human immunodeficiency virus
interferons
therapeutic efficacy
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00637-18

Internet

https://journals.asm.org/doi/10.1128/mSphere.00637-18

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