Cholesterol suppresses human iTreg differentiation and nTreg function through mitochondria-related mechanisms

Cholesterol suppresses human iTreg differentiation and nTreg function through mitochondria-related mechanisms

Abstract Background Both the crystalline and soluble forms of cholesterol increase macrophage secretion of interleukin 1β (IL-1β), aggravating the inflammatory response in atherosclerosis (AS). However, the link between cholesterol and regulatory T cells (Tregs) remains unclear. This study aimed to...

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Bibliographic Details
Main Authors: Huanzhi Zhang, Ni Xia, Tingting Tang, Shaofang Nie, Lingfeng Zha, Min Zhang, Bingjie Lv, Yuzhi Lu, Jiao Jiao, Jingyong Li, Xiang Cheng
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
Atherosclerosis
Regulatory T cells
Cholesterol
Mitochondrial reactive oxygen species
mitoTEMPO
Online Access:https://doi.org/10.1186/s12967-023-03896-z

Internet

https://doi.org/10.1186/s12967-023-03896-z

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