Evaluation of circulating tumor DNA by electropherogram analysis and methylome profiling in high-risk neuroblastomas

Evaluation of circulating tumor DNA by electropherogram analysis and methylome profiling in high-risk neuroblastomas

BackgroundLiquid biopsy has emerged as a promising, non-invasive diagnostic approach in oncology because the analysis of circulating tumor DNA (ctDNA) reflects the precise status of the disease at diagnosis, progression, and response to treatment. DNA methylation profiling is also a potential soluti...

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Bibliographic Details
Main Authors: Eva María Trinidad, Antonio Juan-Ribelles, Giulia Pisano, Victoria Castel, Adela Cañete, Marta Gut, Simon Heath, Jaime Font de Mora
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
liquid biopsy
high-risk neuroblastoma
DNA mehtylation
ctDNA / normal cfDNA ratio
enzymatic methyl-sequencing (EM-seq)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1037342/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1037342/full

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