Toll-Like Receptor 2 mediates in vivo pro- and anti-inflammatory effects of Mycobacterium tuberculosis and modulates autoimmune encephalomyelitis

Toll-Like Receptor 2 mediates in vivo pro- and anti-inflammatory effects of Mycobacterium tuberculosis and modulates autoimmune encephalomyelitis

Mycobacteria display pro- and anti-inflammatory effects in human and experimental pathology. We show here that both effects are mediated by Toll like receptor 2 (Tlr2), by exploiting a previously characterized Tlr2 variant (Met82Ile). Tlr2 82ile promoted self-specific pro-inflammatory polarization a...

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Bibliographic Details
Main Authors: Alessia ePiermattei, Giuseppe eMigliara, Gabriele eDi Sante, Maria eFoti, Soren Bohos Hayrabedyan, Angela ePapagna, Maria Concetta eGeloso, Maddalena eCorbi, Mariagrazia eValentini, Alessandro eSgambato, Giovanni eDelogu, Gabriela eConstantin, Francesco eRia
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Immunology
Subjects:
Host-Pathogen Interactions
Inflammation
Foxp3
TLR2
EAE/MS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00191/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00191/full

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