Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in App NL-G-F , App NL-F , and 3xTg-AD mouse models

Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in App NL-G-F , App NL-F , and 3xTg-AD mouse models

Abstract Background In spite of many years of research, our understanding of the molecular bases of Alzheimer’s disease (AD) is still incomplete, and the medical treatments available mainly target the disease symptoms and are hardly effective. Indeed, the modulation of a single target (e.g., β-secre...

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Bibliographic Details
Main Authors: Eduardo Pauls, Sergi Bayod, Lídia Mateo, Víctor Alcalde, Teresa Juan-Blanco, Marta Sánchez-Soto, Takaomi C. Saido, Takashi Saito, Antoni Berrenguer-Llergo, Camille Stephan-Otto Attolini, Marina Gay, Eliandre de Oliveira, Miquel Duran-Frigola, Patrick Aloy
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Genome Medicine
Subjects:
Alzheimer’s disease
Transcriptomics
Proteomics
Data-driven drug discovery
In vivo models
Online Access:https://doi.org/10.1186/s13073-021-00983-y

Internet

https://doi.org/10.1186/s13073-021-00983-y

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