Metabolic reprogramming in mutant IDH1 glioma cells.

Metabolic reprogramming in mutant IDH1 glioma cells.

<h4>Background</h4>Mutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70% of low-grade gliomas and secondary glioblastomas. IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while mutant IDH1 catalyzes the conversion of...

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Bibliographic Details
Main Authors: Jose L Izquierdo-Garcia, Pavithra Viswanath, Pia Eriksson, Myriam M Chaumeil, Russell O Pieper, Joanna J Phillips, Sabrina M Ronen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118781&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118781&type=printable

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