Notch and TLR signaling coordinate monocyte cell fate and inflammation

Notch and TLR signaling coordinate monocyte cell fate and inflammation

Conventional Ly6Chi monocytes have developmental plasticity for a spectrum of differentiated phagocytes. Here we show, using conditional deletion strategies in a mouse model of Toll-like receptor (TLR) 7-induced inflammation, that the spectrum of developmental cell fates of Ly6Chi monocytes, and the...

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Bibliographic Details
Main Authors: Jaba Gamrekelashvili, Tamar Kapanadze, Stefan Sablotny, Corina Ratiu, Khaled Dastagir, Matthias Lochner, Susanne Karbach, Philip Wenzel, Andre Sitnow, Susanne Fleig, Tim Sparwasser, Ulrich Kalinke, Bernhard Holzmann, Hermann Haller, Florian P Limbourg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
inflammation
monocytes and macrophages
notch signaling
macrophage differentiation
TLR signaling
Online Access:https://elifesciences.org/articles/57007

Internet

https://elifesciences.org/articles/57007

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