mPPases create a conserved anionic membrane fingerprint as identified via multi-scale simulations.

Membrane-integral pyrophosphatases (mPPases) are membrane-bound enzymes responsible for hydrolysing inorganic pyrophosphate and translocating a cation across the membrane. Their function is essential for the infectivity of clinically relevant protozoan parasites and plant maturation. Recent developm...

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Bibliographic Details
Main Authors: Alexandra O M Holmes, Adrian Goldman, Antreas C Kalli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-10-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010578