Glycolaldehyde, an Advanced Glycation End Products Precursor, Induces Apoptosis via ROS-Mediated Mitochondrial Dysfunction in Renal Mesangial Cells

Glycolaldehyde, an Advanced Glycation End Products Precursor, Induces Apoptosis via ROS-Mediated Mitochondrial Dysfunction in Renal Mesangial Cells

Glycolaldehyde (GA) is a reducing sugar and a precursor of advanced glycation end products (AGEs). The role of precursor and precursor-derived AGEs in diabetes and its complications have been actively discussed in the literature. This study aimed to elucidate the mechanism of GA-induced apoptosis in...

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Bibliographic Details
Main Authors: Min Ji Gu, Ju-Youg Hyon, Hee-Weon Lee, Eun Hee Han, Yoonsook Kim, Youn-Soo Cha, Sang Keun Ha
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Antioxidants
Subjects:
glycolaldehyde
advanced glycation end products
apoptosis
mesangial cell
oxidative stress
mitochondrial dysfunction
Online Access:https://www.mdpi.com/2076-3921/11/5/934

Internet

https://www.mdpi.com/2076-3921/11/5/934

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