Natural history of type 1 diabetes on an immunodysregulatory background with genetic alteration in B-cell activating factor receptor: A case report

Natural history of type 1 diabetes on an immunodysregulatory background with genetic alteration in B-cell activating factor receptor: A case report

The immunological events leading to type 1 diabetes (T1D) are complex and heterogeneous, underscoring the necessity to study rare cases to improve our understanding. Here, we report the case of a 16-year-old patient who showed glycosuria during a regular checkup. Upon further evaluation, stage 2 T1D...

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Main Authors: Biagio Di Lorenzo, Lucia Pacillo, Giulia Milardi, Tatiana Jofra, Silvia Di Cesare, Jolanda Gerosa, Ilaria Marzinotto, Ettore Zapparoli, Beatrice Rivalta, Cristina Cifaldi, Federica Barzaghi, Carmela Giancotta, Paola Zangari, Novella Rapini, Annalisa Deodati, Giada Amodio, Laura Passerini, Paola Carrera, Silvia Gregori, Paolo Palma, Andrea Finocchi, Vito Lampasona, Maria Pia Cicalese, Riccardo Schiaffini, Gigliola Di Matteo, Ivan Merelli, Matteo Barcella, Alessandro Aiuti, Lorenzo Piemonti, Caterina Cancrini, Georgia Fousteri
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes (T1D)
common variable immunodeficiency (CVID)
BAFFR mutation
islet autoimmunity
circulating T follicular helper cells (cTfh)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.952715/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.952715/full

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