Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase

Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase

The FTO protein is involved in a wide range of physiological processes, including adipogenesis and osteogenesis. This two-domain protein belongs to the AlkB family of 2-oxoglutarate (2-OG)- and Fe(II)-dependent dioxygenases, displaying <i>N</i><sup>6</sup>-methyladenosine (&l...

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Bibliographic Details
Main Authors: Michał Marcinkowski, Tomaš Pilžys, Damian Garbicz, Jan Piwowarski, Damian Mielecki, Grzegorz Nowaczyk, Michał Taube, Maciej Gielnik, Maciej Kozak, Maria Winiewska-Szajewska, Ewa Szołajska, Janusz Dębski, Agnieszka M. Maciejewska, Kaja Przygońska, Karolina Ferenc, Elżbieta Grzesiuk, Jarosław Poznański
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
<sup>EC</sup>FTO
<sup>BES</sup>FTO
phosphorylation
calcium
dimerization
nanoDSF
Online Access:https://www.mdpi.com/1422-0067/22/9/4512

Internet

https://www.mdpi.com/1422-0067/22/9/4512

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