PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production is promoted by autoreactive T follicular helper (TFH) cells. During SLE pathogenesis, basophils accumulate in secondary lymphoid organs (SLO), amplify autoantibody produ...

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Bibliographic Details
Main Authors: John TCHEN, Quentin SIMON, Léa CHAPART, Morgane K. THAMINY, Shamila VIBHUSHAN, Loredana SAVEANU, Yasmine LAMRI, Fanny SAIDOUNE, Emeline PACREAU, Christophe PELLEFIGUES, Julie BEX-COUDRAT, Hajime KARASUYAMA, Kensuke MIYAKE, Juan HIDALGO, Padraic G. FALLON, Thomas PAPO, Ulrich BLANK, Marc BENHAMOU, Guillaume HANOUNA, Karim SACRE, Eric DAUGAS, Nicolas CHARLES
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47691-w

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https://doi.org/10.1038/s41467-024-47691-w

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