Nitrogen-Containing Bisphosphonates Downregulate Cathepsin K and Upregulate Annexin V in Osteoclasts Cultured In Vitro

Introduction. Bisphosphonates are widely used in the treatment of osteoporosis; however, they are associated with the serious adverse event of bisphosphonate‐related osteonecrosis of the jaw (BRONJ). Aim. The aim of this study is to assess the effects of nitrogen-containing bisphosphonates (N-PHs) o...

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Bibliographic Details
Main Authors: Arturo Bautista-Carbajal, Rosina Eugenia Villanueva-Arriaga, Araceli Páez-Arenas, Felipe Massó-Rojas, Nelly Frechero Molina, Salvador García-López
Format: Article
Language:English
Published: Hindawi Limited 2023-01-01
Series:International Journal of Dentistry
Online Access:http://dx.doi.org/10.1155/2023/2960941