Cyclosporine A-resistant CAR-T cells mediate antitumour immunity in the presence of allogeneic cells

Cyclosporine A-resistant CAR-T cells mediate antitumour immunity in the presence of allogeneic cells

Abstract Chimeric antigen receptor (CAR)-T therapy requires autologous T lymphocytes from cancer patients, a process that is both costly and complex. Universal CAR-T cell treatment from allogeneic sources can overcome this limitation but is impeded by graft-versus-host disease (GvHD) and host versus...

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Bibliographic Details
Main Authors: Yixi Zhang, Hongyu Fang, Guocan Wang, Guangxun Yuan, Ruoyu Dong, Jijun Luo, Yu Lyu, Yajie Wang, Peng Li, Chun Zhou, Weiwei Yin, Haowen Xiao, Jie Sun, Xun Zeng
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44176-0

Internet

https://doi.org/10.1038/s41467-023-44176-0

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