Efficient Sustained-Release Nanoparticle Delivery System Protects Nigral Neurons in a Toxin Model of Parkinson’s Disease

Efficient Sustained-Release Nanoparticle Delivery System Protects Nigral Neurons in a Toxin Model of Parkinson’s Disease

Parkinson’s disease (PD) is a serious neurodegenerative disease wherein the progressive destruction of dopaminergic neurons results in a series of related movement disorders. Effective oral delivery of anti-Parkinson’s drugs is challenging owing to the blood-brain barrier (BBB) and the limited plasm...

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Bibliographic Details
Main Authors: Qun Wang, Rui Ma, Piaoxue Liu, Guowang Cheng, Qi Yang, Xiaojia Chen, Zhenfeng Wu, Dongsheng Yuan, Tongkai Chen
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
polymeric nanoparticles
blood-brain barrier
drug delivery
pharmacokinetics
brain accumulation
parkinsonian therapy
Online Access:https://www.mdpi.com/1999-4923/14/8/1731

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https://www.mdpi.com/1999-4923/14/8/1731

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