N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease

N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease

Abstract Background Synaptic degeneration occurs in the early stage of Alzheimer's disease (AD) before devastating symptoms, strongly correlated with cognitive decline. Circular RNAs (circRNAs) are abundantly enriched in neural tissues, and aberrant expression of circRNAs precedes AD symptoms,...

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Bibliographic Details
Main Authors: Xiong Wang, Jiazhao Xie, Lu Tan, Yanjun Lu, Na Shen, Jiaoyuan Li, Hui Hu, Huijun Li, Xiaoguang Li, Liming Cheng
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
circRNA
Synaptic dysfunction
GluN2B
Ubiquitination
Online Access:https://doi.org/10.1186/s40035-023-00386-6

Internet

https://doi.org/10.1186/s40035-023-00386-6

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