Tyrosine 7.43 is important for mu-opioid receptor downstream signaling pathways activated by fentanyl

Tyrosine 7.43 is important for mu-opioid receptor downstream signaling pathways activated by fentanyl

G protein–coupled receptors can signal through both G proteins and ß-arrestin2. For the µ-opioid receptor (MOR), early experimental evidence from a single study suggested that G protein signaling mediates analgesia and sedation, whereas ß-arrestin signaling mediates respiratory depression and consti...

Full description

Bibliographic Details
Main Authors: Xiangyun Tian, Junjie Zhang, Shaowen Wang, Huan Gao, Yi Sun, Xiaoqian Liu, Wei Fu, Bo Tan, Ruibin Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
μ-opioid receptor
molecular docking
cAMP
β-arrestin2 recruitment
signaling pathway
analgesia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.919325/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.919325/full

Similar Items