The Impact of SRT2104 on Skeletal Muscle Mitochondrial Function, Redox Biology, and Loss of Muscle Mass in Hindlimb Unloaded Rats

The Impact of SRT2104 on Skeletal Muscle Mitochondrial Function, Redox Biology, and Loss of Muscle Mass in Hindlimb Unloaded Rats

Mechanical unloading during microgravity causes skeletal muscle atrophy and impairs mitochondrial energetics. The elevated production of reactive oxygen species (ROS) by mitochondria and Nox2, coupled with impairment of stress protection (e.g., SIRT1, antioxidant enzymes), contribute to atrophy. We...

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Bibliographic Details
Main Authors: Lauren T. Wesolowski, Jessica L. Simons, Pier L. Semanchik, Mariam A. Othman, Joo-Hyun Kim, John M. Lawler, Khaled Y. Kamal, Sarah H. White-Springer
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
hindlimb unloading
spaceflight
skeletal muscle
electron transfer system
SRT2104
mitochondria
Online Access:https://www.mdpi.com/1422-0067/24/13/11135

Internet

https://www.mdpi.com/1422-0067/24/13/11135

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