Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming

Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming

Obesity promotes dysfunction and impairs the reparative capacity of mesenchymal stem/stromal cells (MSCs), and alters their transcription, protein content, and paracrine function. Whether these adverse effects are mediated by chromatin-modifying epigenetic changes remains unclear. We tested the hypo...

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Bibliographic Details
Main Authors: Mohsen Afarideh, Roman Thaler, Farzaneh Khani, Hui Tang, Kyra L. Jordan, Sabena M. Conley, Ishran M. Saadiq, Yasin Obeidat, Aditya S. Pawar, Alfonso Eirin, Xiang-Yang Zhu, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman
Format: Article
Language:English
Published: Taylor & Francis Group 2021-07-01
Series:Epigenetics
Subjects:
epigenetics
obesity
dna hydroxymethylation
histone tri-methylation
vitamin c
Online Access:http://dx.doi.org/10.1080/15592294.2020.1819663

Internet

http://dx.doi.org/10.1080/15592294.2020.1819663

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