Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways

Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways

Missense mutations of ubiquilin 2 (UBQLN2) have been identified to cause X-linked amyotrophic lateral sclerosis (ALS). Proteasome-mediated protein degradation is reported to be impaired by ALS-associated mutations of UBQLN2. However, it remains unknown how these mutations affect autophagy-lysosome p...

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Bibliographic Details
Main Authors: Akiko Idera, Lisa M. Sharkey, Yuki Kurauchi, Keiichi Kadoyama, Henry L. Paulson, Hiroshi Katsuki, Takahiro Seki
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Journal of Pharmacological Sciences
Subjects:
Amyotrophic lateral sclerosis
Ubiquilin 2
Chaperone-mediated autophagy
Macroautophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000324

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http://www.sciencedirect.com/science/article/pii/S1347861323000324

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