Rapid Low-Cost Microarray-Based Genotyping for Genetic Screening in Primary Immunodeficiency

Rapid Low-Cost Microarray-Based Genotyping for Genetic Screening in Primary Immunodeficiency

Background: Genetic tests for primary immunodeficiency disorders (PIDs) are expensive, time-consuming, and not easily accessible in developing countries. Therefore, we studied the feasibility of a customized single nucleotide variant (SNV) microarray that we developed to detect disease-causing varia...

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Main Authors: Narissara Suratannon, Rogier T. A. van Wijck, Linda Broer, Laixi Xue, Joyce B. J. van Meurs, Barbara H. Barendregt, Mirjam van der Burg, Willem A. Dik, Pantipa Chatchatee, Anton W. Langerak, Sigrid M. A. Swagemakers, Jacqueline A. C. Goos, Irene M. J. Mathijssen, Virgil A. S. H. Dalm, Kanya Suphapeetiporn, Kim C. Heezen, Jose Drabwell, André G. Uitterlinden, Peter J. van der Spek, P. Martin van Hagen, The South East Asia Primary Immunodeficiencies (SEAPID) Consortium
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
primary immunodeficiencies
microarray-based genotyping
SNP microarray
single nucleotide variants (SNV) calling
copy number variants (CNV) calling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00614/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00614/full

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