CRISPR-Cas and catalytic hairpin assembly technology for target-initiated amplification detection of pancreatic cancer specific tsRNAs

CRISPR-Cas and catalytic hairpin assembly technology for target-initiated amplification detection of pancreatic cancer specific tsRNAs

Transfer RNA-derived small RNAs (tsRNAs) tRF-LeuCAG-002 (ts3011a RNA) is a novel class of non-coding RNAs biomarker for pancreatic cancer (PC). Reverse transcription polymerase chain reaction (RT-qPCR) has been unfit for community hospitals that are short of specialized equipment or laboratory setup...

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Bibliographic Details
Main Authors: Jie Wu, Hongpan Xu, Fenghua Hu, Yiyue Jiang, Boyue Fan, Adeel Khan, Yifan Sun, Kaili Di, Xinrui Gu, Han Shen, Zhiyang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
pancreatic cancer
tsRNAs
CRISPR-Cas12a
catalytic hairpin assembly
target-initiated amplification
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1169424/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1169424/full

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