Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex

Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex

Cellular senescence is a crucial tumor suppressor mechanism. We discovered a CAPERα/TBX3 repressor complex required to prevent senescence in primary cells and mouse embryos. Critical, previously unknown roles for CAPERα in controlling cell proliferation are manifest in an obligatory interaction with...

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Bibliographic Details
Main Authors: Pavan Kumar P, Uchenna Emechebe, Richard Smith, Sarah Franklin, Barry Moore, Mark Yandell, Stephen L Lessnick, Anne M Moon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
senescence
oncogenesis
development
p16
Online Access:https://elifesciences.org/articles/02805

Internet

https://elifesciences.org/articles/02805

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