A study of roflumilast treatment on functional and structural changes in hippocampus in depressed Adult male Wistar rats.

Depression is a common stress disability disorder that affects higher mental functions including emotion, cognition, and behavior. It may be mediated by inflammatory cytokines that interfere with neuroendocrine function, and synaptic plasticity. Therefore, reductions in inflammation might contribute...

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Bibliographic Details
Main Authors: Ghida Hassan, Sherif A Kamar, Hagar Yousry Rady, Dina Sayed Abdelrahim, Nesma Hussein Abdel Hay Ibrahim, Noha N Lasheen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0296187